★ WIDE MOAT STOCKS COMPARISON ★

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Stock Comparison

Amgen Inc. vs Pfizer Inc.

Compare moat strength, market structure, and segment coverage to understand how each company defends its edge.

Amgen Inc.

AMGN · Nasdaq Stock Market

Market cap (USD)$177.2B
Gross margin (TTM)71.5%
Operating margin (TTM)31.6%
Net margin (TTM)21%
SectorHealthcare
IndustryDrug Manufacturers - General
CountryUS
Data as of2026-07-12
Moat score
76/ 100

Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.

Full stock profile

Dive deeper into Amgen Inc.'s moat claims, evidence, and risks.

View AMGN analysis

Pfizer Inc.

PFE · New York Stock Exchange

Market cap (USD)$145.6B
Gross margin (TTM)69.4%
Operating margin (TTM)23.5%
Net margin (TTM)11.8%
SectorHealthcare
IndustryDrug Manufacturers - General
CountryUS
Data as of2026-07-12
Moat score
68/ 100

Partial score covering 85% of segment weight.

Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.

Full stock profile

Dive deeper into Pfizer Inc.'s moat claims, evidence, and risks.

View PFE analysis

Comparison highlights

  • Segment focus: Amgen Inc. has 3 segments (76.1% in Core Innovative Medicines); Pfizer Inc. has 5 segments (38.4% in Primary Care).
  • Primary market structure: Competitive vs Oligopoly. Pricing power: Moderate vs Moderate.
  • Moat breadth: Amgen Inc. has 2 moat types across 2 domains; Pfizer Inc. has 1 across 1.

Primary market context

Amgen Inc.

Core Innovative Medicines

Market

Branded biopharmaceutical therapies for common diseases (bone health, inflammation, oncology, cardiovascular and other specialty areas)

Geography

Global

Customer

Payers, providers, and pharmacies

Role

Drug developer/manufacturer

Revenue share

76.1%

Pfizer Inc.

Primary Care

Market

Branded primary care medicines and vaccines (incl. cardiovascular, migraine, pneumococcal/RSV/COVID-19)

Geography

Global

Customer

Healthcare providers, payers/PBMs, pharmacies/wholesalers, and government procurement

Role

Innovator biopharma (R&D + manufacturing + commercialization)

Revenue share

38.4%

Side-by-side metrics

Amgen Inc.
Pfizer Inc.
Ticker / Exchange
AMGN - Nasdaq Stock Market
PFE - New York Stock Exchange
Market cap (USD)
$177.2B
$145.6B
Gross margin (TTM)
71.5%
69.4%
Operating margin (TTM)
31.6%
23.5%
Net margin (TTM)
21%
11.8%
Sector
Healthcare
Healthcare
Industry
Drug Manufacturers - General
Drug Manufacturers - General
HQ country
US
US
Primary segment
Core Innovative Medicines
Primary Care
Market structure
Competitive
Oligopoly
Market share
n/a
n/a
HHI estimate
n/a
n/a
Pricing power
Moderate
Moderate
Moat score
76 / 100
68 / 100 (partial, 85% coverage)
Moat domains
Legal, Supply
Legal
Last update
2026-07-12
2026-07-12

Moat coverage

Shared moat types

IP Choke Point

Amgen Inc. strengths

Capex Knowhow Scale

Pfizer Inc. strengths

No unique moat types yet.

Segment mix

Amgen Inc. segments

Full profile >

Core Innovative Medicines

Competitive

76.1%

Rare Disease Portfolio (Horizon + others)

Quasi-Monopoly

14.2%

Biosimilars

Oligopoly

9.7%

Pfizer Inc. segments

Full profile >

Primary Care

Oligopoly

38.4%

Specialty Care

Oligopoly

20.3%

Oncology

Competitive

26.5%

Hospital and Biosimilars

Competitive

12.8%

Pfizer CentreOne

Competitive

2%

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Curation & Accuracy

This directory blends AI‑assisted discovery with human curation. Entries are reviewed, edited, and organized with the goal of expanding coverage and sharpening quality over time. Your feedback helps steer improvements (because no single human can capture everything all at once).

Details change. Pricing, features, and availability may be incomplete or out of date. Treat listings as a starting point and verify on the provider’s site before making decisions. If you spot an error or a gap, send a quick note and I’ll adjust.