WIDE MOAT STOCKS COMPARISON

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Stock Comparison

Pfizer Inc. vs Roche Holding AG

Compare moat strength, market structure, and segment coverage to understand how each company defends its edge.

Pfizer Inc.

PFE · New York Stock Exchange

Market cap (USD)$159.5B
Gross margin (TTM)73.2%
Operating margin (TTM)21.7%
Net margin (TTM)6.8%
SectorHealthcare
IndustryPharmaceuticals
CountryUS
Data as of2026-08-23
58/100
Moat score

Weighted across the company's segments.

Full stock profile

Dive deeper into Pfizer Inc.'s moat claims, evidence, and risks.

View PFE analysis

Roche Holding AG

ROP · SIX Swiss Exchange (participation certificate)

Market cap (USD)$334.5B
Gross margin (TTM)72.7%
Operating margin (TTM)29.2%
Net margin (TTM)20.3%
SectorHealthcare
IndustryPharmaceuticals
CountryCH
Data as of2026-08-23
69/100
Moat score

Weighted across the company's segments.

Full stock profile

Dive deeper into Roche Holding AG's moat claims, evidence, and risks.

View ROP analysis

Comparison highlights

  • Moat score gap: Roche Holding AG leads (69 / 100 vs 58 / 100 for Pfizer Inc.).
  • Segment focus: Pfizer Inc. has 5 segments (37.5% in Primary Care); Roche Holding AG has 2 segments (77.8% in Pharmaceuticals).
  • Primary market structure: Oligopoly vs Competitive. Pricing power: Moderate vs Moderate.
  • Moat breadth: Pfizer Inc. has 1 moat types across 1 domains; Roche Holding AG has 3 across 2.

Primary market context

Pfizer Inc.

Primary Care

Market

Branded primary care medicines and vaccines (incl. cardiovascular, migraine, pneumococcal/RSV/COVID-19)

Geography

Global

Customer

Healthcare providers, payers/PBMs, pharmacies/wholesalers, and government procurement

Role

Innovator biopharma (R&D + manufacturing + commercialization)

Revenue share

37.5%

Roche Holding AG

Pharmaceuticals

Market

Innovative (branded) prescription pharmaceuticals

Geography

Global

Customer

Healthcare providers and systems (hospitals/clinics), payers/governments, and patients

Role

Innovator pharmaceutical developer, manufacturer and marketer

Revenue share

77.8%

Side-by-side metrics

Pfizer Inc.
Roche Holding AG
Ticker / Exchange
PFE - New York Stock Exchange
ROP - SIX Swiss Exchange (participation certificate)
Market cap (USD)
$159.5B
$334.5B
Gross margin (TTM)
73.2%
72.7%
Operating margin (TTM)
21.7%
29.2%
Net margin (TTM)
6.8%
20.3%
Sector
Healthcare
Healthcare
Industry
Pharmaceuticals
Pharmaceuticals
HQ country
US
CH
Primary segment
Primary Care
Pharmaceuticals
Market structure
Oligopoly
Competitive
Market share
n/a
n/a
HHI estimate
n/a
n/a
Pricing power
Moderate
Moderate
Moat score
58 / 100
69 / 100
Moat domains
Legal
Legal, Demand
Last update
2026-09-05
2026-09-05

Moat coverage

Shared moat types

IP Choke Point

Pfizer Inc. strengths

No unique moat types yet.

Roche Holding AG strengths

Installed Base ConsumablesData Workflow Lockin

Segment mix

Pfizer Inc. segments

Full profile >

Primary Care

Oligopoly

37.5%

Specialty Care

Oligopoly

21.3%

Oncology

Competitive

27.1%

Hospital and Biosimilars

Competitive

11.9%

Pfizer CentreOne

Competitive

2.2%

Roche Holding AG segments

Full profile >

Pharmaceuticals

Competitive

77.8%

Diagnostics

Oligopoly

22.2%

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Curation & Accuracy

This directory blends AI‑assisted discovery with human curation. Entries are reviewed, edited, and organized with the goal of expanding coverage and sharpening quality over time. Your feedback helps steer improvements (because no single human can capture everything all at once).

Details change. Pricing, features, and availability may be incomplete or out of date. Treat listings as a starting point and verify on the provider’s site before making decisions. If you spot an error or a gap, send a quick note and I’ll adjust.