WIDE MOAT STOCKS COMPARISON

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Stock Comparison

Gilead Sciences, Inc. vs Pfizer Inc.

Compare moat strength, market structure, and segment coverage to understand how each company defends its edge.

Gilead Sciences, Inc.

GILD · NASDAQ Global Select Market

Market cap (USD)$187.5B
Gross margin (TTM)79.6%
Operating margin (TTM)-4.9%
Net margin (TTM)-10.6%
SectorHealthcare
IndustryDrug Manufacturers - General
CountryUS
Data as of2026-08-23
76/100
Moat score

Weighted across the company's segments.

Full stock profile

Dive deeper into Gilead Sciences, Inc.'s moat claims, evidence, and risks.

View GILD analysis

Pfizer Inc.

PFE · New York Stock Exchange

Market cap (USD)$162.1B
Gross margin (TTM)71.3%
Operating margin (TTM)25.1%
Net margin (TTM)6.8%
SectorHealthcare
IndustryDrug Manufacturers - General
CountryUS
Data as of2026-08-23
58/100
Moat score

Weighted across the company's segments.

Full stock profile

Dive deeper into Pfizer Inc.'s moat claims, evidence, and risks.

View PFE analysis

Comparison highlights

  • Moat score gap: Gilead Sciences, Inc. leads (76 / 100 vs 58 / 100 for Pfizer Inc.).
  • Segment focus: Gilead Sciences, Inc. has 5 segments (74.6% in HIV); Pfizer Inc. has 5 segments (37.5% in Primary Care).
  • Moat breadth: Gilead Sciences, Inc. has 3 moat types across 3 domains; Pfizer Inc. has 1 across 1.

Primary market context

Gilead Sciences, Inc.

HIV

Market

HIV treatment and prevention medicines (antiretroviral therapy and PrEP)

Geography

Global (U.S. and Europe are major markets)

Customer

Patients/prescribers; reimbursed by public and private payers; distributed via wholesalers and specialty pharmacies

Role

Drug developer and marketing authorization holder

Revenue share

74.6%

Pfizer Inc.

Primary Care

Market

Branded primary care medicines and vaccines (incl. cardiovascular, migraine, pneumococcal/RSV/COVID-19)

Geography

Global

Customer

Healthcare providers, payers/PBMs, pharmacies/wholesalers, and government procurement

Role

Innovator biopharma (R&D + manufacturing + commercialization)

Revenue share

37.5%

Side-by-side metrics

Gilead Sciences, Inc.
Pfizer Inc.
Ticker / Exchange
GILD - NASDAQ Global Select Market
PFE - New York Stock Exchange
Market cap (USD)
$187.5B
$162.1B
Gross margin (TTM)
79.6%
71.3%
Operating margin (TTM)
-4.9%
25.1%
Net margin (TTM)
-10.6%
6.8%
Sector
Healthcare
Healthcare
Industry
Drug Manufacturers - General
Drug Manufacturers - General
HQ country
US
US
Primary segment
HIV
Primary Care
Market structure
Oligopoly
Oligopoly
Market share
n/a
n/a
HHI estimate
n/a
n/a
Pricing power
Moderate
Moderate
Moat score
76 / 100
58 / 100
Moat domains
Network, Legal, Supply
Legal
Last update
2026-09-05
2026-09-05

Moat coverage

Shared moat types

IP Choke Point

Gilead Sciences, Inc. strengths

De Facto StandardCapex Knowhow Scale

Pfizer Inc. strengths

No unique moat types yet.

Segment mix

Gilead Sciences, Inc. segments

Full profile >

HIV

Oligopoly

74.6%

Oncology (Cell Therapy + Trodelvy)

Oligopoly

11.4%

Liver Disease

Oligopoly

11.5%

Veklury (Remdesivir)

Competitive

0.3%

Other Products

Competitive

2.1%

Pfizer Inc. segments

Full profile >

Primary Care

Oligopoly

37.5%

Specialty Care

Oligopoly

21.3%

Oncology

Competitive

27.1%

Hospital and Biosimilars

Competitive

11.9%

Pfizer CentreOne

Competitive

2.2%

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Curation & Accuracy

This directory blends AI‑assisted discovery with human curation. Entries are reviewed, edited, and organized with the goal of expanding coverage and sharpening quality over time. Your feedback helps steer improvements (because no single human can capture everything all at once).

Details change. Pricing, features, and availability may be incomplete or out of date. Treat listings as a starting point and verify on the provider’s site before making decisions. If you spot an error or a gap, send a quick note and I’ll adjust.