VOL. XCIV, NO. 247
★ WIDE MOAT STOCKS COMPARISON ★
NO ADVICE
Wednesday, December 31, 2025
Stock Comparison
Amgen Inc. vs American Express Company
Compare moat strength, market structure, and segment coverage to understand how each company defends its edge.
Amgen Inc.
AMGN · Nasdaq Stock Market
Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.
American Express Company
AXP · New York Stock Exchange
Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.
Full stock profile
Dive deeper into American Express Company's moat claims, evidence, and risks.
View AXP analysisComparison highlights
- Moat score gap: Amgen Inc. leads (70 / 100 vs 52 / 100 for American Express Company).
- Segment focus: Amgen Inc. has 3 segments (80.1% in Core Innovative Medicines); American Express Company has 4 segments (47.5% in U.S. Consumer Services (USCS)).
- Primary market structure: Competitive vs Competitive. Pricing power: Moderate vs n/a.
- Moat breadth: Amgen Inc. has 5 moat types across 3 domains; American Express Company has 8 across 3.
Primary market context
Amgen Inc.
Core Innovative Medicines
Branded biopharmaceutical therapies for common diseases (bone health, inflammation, oncology, cardiovascular and other specialty areas)
Global
Payers, providers, and pharmacies
Drug developer/manufacturer
80.1%
American Express Company
U.S. Consumer Services (USCS)
U.S. premium consumer card issuing (charge and credit) and attached consumer banking and financing
United States
Consumers
Issuer (proprietary cards) and consumer lender/services
47.5%
Side-by-side metrics
Moat coverage
Shared moat types
Amgen Inc. strengths
American Express Company strengths
Segment mix
Amgen Inc. segments
Full profile >Core Innovative Medicines
Competitive
Rare Disease Portfolio (Horizon + others)
Quasi-Monopoly
Biosimilars
Oligopoly
American Express Company segments
Full profile >U.S. Consumer Services (USCS)
Competitive
Commercial Services (CS)
Competitive
International Card Services (ICS)
Competitive
Global Merchant and Network Services (GMNS)
Oligopoly
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View the moat stocks listCuration & Accuracy
This directory blends AI‑assisted discovery with human curation. Entries are reviewed, edited, and organized with the goal of expanding coverage and sharpening quality over time. Your feedback helps steer improvements (because no single human can capture everything all at once).
Details change. Pricing, features, and availability may be incomplete or out of date. Treat listings as a starting point and verify on the provider’s site before making decisions. If you spot an error or a gap, send a quick note and I’ll adjust.