VOL. XCIV, NO. 247
★ WIDE MOAT STOCKS COMPARISON ★
NO ADVICE
Wednesday, December 31, 2025
Stock Comparison
American Express Company vs Gilead Sciences, Inc.
Compare moat strength, market structure, and segment coverage to understand how each company defends its edge.
American Express Company
AXP · New York Stock Exchange
Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.
Full stock profile
Dive deeper into American Express Company's moat claims, evidence, and risks.
View AXP analysisGilead Sciences, Inc.
GILD · NASDAQ Global Select Market
Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.
Full stock profile
Dive deeper into Gilead Sciences, Inc.'s moat claims, evidence, and risks.
View GILD analysisComparison highlights
- Moat score gap: Gilead Sciences, Inc. leads (74 / 100 vs 52 / 100 for American Express Company).
- Segment focus: American Express Company has 4 segments (47.5% in U.S. Consumer Services (USCS)); Gilead Sciences, Inc. has 5 segments (68.5% in HIV).
- Primary market structure: Competitive vs Oligopoly. Pricing power: n/a vs Moderate.
- Moat breadth: American Express Company has 8 moat types across 3 domains; Gilead Sciences, Inc. has 8 across 3.
Primary market context
American Express Company
U.S. Consumer Services (USCS)
U.S. premium consumer card issuing (charge and credit) and attached consumer banking and financing
United States
Consumers
Issuer (proprietary cards) and consumer lender/services
47.5%
Gilead Sciences, Inc.
HIV
HIV treatment and prevention medicines (antiretroviral therapy and PrEP)
Global (U.S. and Europe are major markets)
Patients/prescribers; reimbursed by public and private payers; distributed via wholesalers and specialty pharmacies
Drug developer and marketing authorization holder
68.5%
Side-by-side metrics
Moat coverage
Shared moat types
American Express Company strengths
Gilead Sciences, Inc. strengths
Segment mix
American Express Company segments
Full profile >U.S. Consumer Services (USCS)
Competitive
Commercial Services (CS)
Competitive
International Card Services (ICS)
Competitive
Global Merchant and Network Services (GMNS)
Oligopoly
Gilead Sciences, Inc. segments
Full profile >HIV
Oligopoly
Oncology (Cell Therapy + Trodelvy)
Oligopoly
Liver Disease
Oligopoly
Veklury (Remdesivir)
Competitive
Other Products
Competitive
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View the moat stocks listCuration & Accuracy
This directory blends AI‑assisted discovery with human curation. Entries are reviewed, edited, and organized with the goal of expanding coverage and sharpening quality over time. Your feedback helps steer improvements (because no single human can capture everything all at once).
Details change. Pricing, features, and availability may be incomplete or out of date. Treat listings as a starting point and verify on the provider’s site before making decisions. If you spot an error or a gap, send a quick note and I’ll adjust.