VOL. XCIV, NO. 247
★ WIDE MOAT STOCKS COMPARISON ★
NO ADVICE
Tuesday, December 30, 2025
Stock Comparison
Gilead Sciences, Inc. vs MarketAxess Holdings Inc.
Compare moat strength, market structure, and segment coverage to understand how each company defends its edge.
Gilead Sciences, Inc.
GILD · NASDAQ Global Select Market
Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.
Full stock profile
Dive deeper into Gilead Sciences, Inc.'s moat claims, evidence, and risks.
View GILD analysisMarketAxess Holdings Inc.
MKTX · NASDAQ Global Select Market
Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.
Full stock profile
Dive deeper into MarketAxess Holdings Inc.'s moat claims, evidence, and risks.
View MKTX analysisComparison highlights
- Moat score: both at 74 / 100.
- Segment focus: Gilead Sciences, Inc. has 5 segments (68.5% in HIV); MarketAxess Holdings Inc. has 2 segments (87.1% in Trade Execution Solutions).
- Moat breadth: Gilead Sciences, Inc. has 8 moat types across 3 domains; MarketAxess Holdings Inc. has 6 across 3.
Primary market context
Gilead Sciences, Inc.
HIV
HIV treatment and prevention medicines (antiretroviral therapy and PrEP)
Global (U.S. and Europe are major markets)
Patients/prescribers; reimbursed by public and private payers; distributed via wholesalers and specialty pharmacies
Drug developer and marketing authorization holder
68.5%
MarketAxess Holdings Inc.
Trade Execution Solutions
Electronic fixed-income trade execution platforms (credit and rates)
Global
Institutional investors, broker-dealers, and alternative liquidity providers
Electronic trading venue / marketplace operator
87.1%
Side-by-side metrics
Moat coverage
Shared moat types
Gilead Sciences, Inc. strengths
MarketAxess Holdings Inc. strengths
Segment mix
Gilead Sciences, Inc. segments
Full profile >HIV
Oligopoly
Oncology (Cell Therapy + Trodelvy)
Oligopoly
Liver Disease
Oligopoly
Veklury (Remdesivir)
Competitive
Other Products
Competitive
MarketAxess Holdings Inc. segments
Full profile >Trade Execution Solutions
Oligopoly
Services (Data, Post-Trade and Technology)
Competitive
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View the moat stocks listCuration & Accuracy
This directory blends AI‑assisted discovery with human curation. Entries are reviewed, edited, and organized with the goal of expanding coverage and sharpening quality over time. Your feedback helps steer improvements (because no single human can capture everything all at once).
Details change. Pricing, features, and availability may be incomplete or out of date. Treat listings as a starting point and verify on the provider’s site before making decisions. If you spot an error or a gap, send a quick note and I’ll adjust.