VOL. XCIV, NO. 247
★ WIDE MOAT STOCKS COMPARISON ★
NO ADVICE
Tuesday, December 30, 2025
Stock Comparison
Booking Holdings Inc. vs Gilead Sciences, Inc.
Compare moat strength, market structure, and segment coverage to understand how each company defends its edge.
Booking Holdings Inc.
BKNG · NASDAQ Global Select Market
Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.
Full stock profile
Dive deeper into Booking Holdings Inc.'s moat claims, evidence, and risks.
View BKNG analysisGilead Sciences, Inc.
GILD · NASDAQ Global Select Market
Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.
Full stock profile
Dive deeper into Gilead Sciences, Inc.'s moat claims, evidence, and risks.
View GILD analysisComparison highlights
- Moat score gap: Booking Holdings Inc. leads (77 / 100 vs 74 / 100 for Gilead Sciences, Inc.).
- Segment focus: Booking Holdings Inc. has 2 segments (95.5% in OTC online travel reservations (Booking.com, Priceline, Agoda)); Gilead Sciences, Inc. has 5 segments (68.5% in HIV).
- Moat breadth: Booking Holdings Inc. has 5 moat types across 4 domains; Gilead Sciences, Inc. has 8 across 3.
Primary market context
Booking Holdings Inc.
OTC online travel reservations (Booking.com, Priceline, Agoda)
Online travel agency (OTA) reservation platforms
Global
Two-sided: travelers (B2C) and travel service providers (B2B)
Intermediary / marketplace
95.5%
Gilead Sciences, Inc.
HIV
HIV treatment and prevention medicines (antiretroviral therapy and PrEP)
Global (U.S. and Europe are major markets)
Patients/prescribers; reimbursed by public and private payers; distributed via wholesalers and specialty pharmacies
Drug developer and marketing authorization holder
68.5%
Side-by-side metrics
Moat coverage
Shared moat types
Booking Holdings Inc. strengths
Gilead Sciences, Inc. strengths
Segment mix
Booking Holdings Inc. segments
Full profile >OTC online travel reservations (Booking.com, Priceline, Agoda)
Oligopoly
Metasearch & restaurant reservations (KAYAK, OpenTable)
Competitive
Gilead Sciences, Inc. segments
Full profile >HIV
Oligopoly
Oncology (Cell Therapy + Trodelvy)
Oligopoly
Liver Disease
Oligopoly
Veklury (Remdesivir)
Competitive
Other Products
Competitive
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View the moat stocks listCuration & Accuracy
This directory blends AI‑assisted discovery with human curation. Entries are reviewed, edited, and organized with the goal of expanding coverage and sharpening quality over time. Your feedback helps steer improvements (because no single human can capture everything all at once).
Details change. Pricing, features, and availability may be incomplete or out of date. Treat listings as a starting point and verify on the provider’s site before making decisions. If you spot an error or a gap, send a quick note and I’ll adjust.