VOL. XCIV, NO. 247
★ WIDE MOAT STOCKS COMPARISON ★
NO ADVICE
Wednesday, December 31, 2025
Stock Comparison
Gilead Sciences, Inc. vs O'Reilly Automotive, Inc.
Compare moat strength, market structure, and segment coverage to understand how each company defends its edge.
Gilead Sciences, Inc.
GILD · NASDAQ Global Select Market
Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.
Full stock profile
Dive deeper into Gilead Sciences, Inc.'s moat claims, evidence, and risks.
View GILD analysisO'Reilly Automotive, Inc.
ORLY · Nasdaq Global Select Market
Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.
Full stock profile
Dive deeper into O'Reilly Automotive, Inc.'s moat claims, evidence, and risks.
View ORLY analysisComparison highlights
- Moat score gap: Gilead Sciences, Inc. leads (74 / 100 vs 63 / 100 for O'Reilly Automotive, Inc.).
- Segment focus: Gilead Sciences, Inc. has 5 segments (68.5% in HIV); O'Reilly Automotive, Inc. has 2 segments (52% in DIY Aftermarket Retail).
- Moat breadth: Gilead Sciences, Inc. has 8 moat types across 3 domains; O'Reilly Automotive, Inc. has 7 across 2.
Primary market context
Gilead Sciences, Inc.
HIV
HIV treatment and prevention medicines (antiretroviral therapy and PrEP)
Global (U.S. and Europe are major markets)
Patients/prescribers; reimbursed by public and private payers; distributed via wholesalers and specialty pharmacies
Drug developer and marketing authorization holder
68.5%
O'Reilly Automotive, Inc.
DIY Aftermarket Retail
Specialty automotive aftermarket parts retail (DIY channel)
United States, Puerto Rico, Mexico, Canada
Consumers (do-it-yourself vehicle owners)
Specialty retailer
52%
Side-by-side metrics
Moat coverage
Shared moat types
Gilead Sciences, Inc. strengths
O'Reilly Automotive, Inc. strengths
Segment mix
Gilead Sciences, Inc. segments
Full profile >HIV
Oligopoly
Oncology (Cell Therapy + Trodelvy)
Oligopoly
Liver Disease
Oligopoly
Veklury (Remdesivir)
Competitive
Other Products
Competitive
O'Reilly Automotive, Inc. segments
Full profile >DIY Aftermarket Retail
Oligopoly
Professional (B2B) Aftermarket Distribution
Competitive
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View the moat stocks listCuration & Accuracy
This directory blends AI‑assisted discovery with human curation. Entries are reviewed, edited, and organized with the goal of expanding coverage and sharpening quality over time. Your feedback helps steer improvements (because no single human can capture everything all at once).
Details change. Pricing, features, and availability may be incomplete or out of date. Treat listings as a starting point and verify on the provider’s site before making decisions. If you spot an error or a gap, send a quick note and I’ll adjust.