VOL. XCIV, NO. 247

★ WIDE MOAT STOCKS COMPARISON ★

NO ADVICE

Stock Comparison

Roche Holding AG vs Thermo Fisher Scientific Inc.

Compare moat strength, market structure, and segment coverage to understand how each company defends its edge.

Roche Holding AG

ROG · SIX Swiss Exchange

Market cap (USD)$292.8B
Gross margin (TTM)73.4%
Operating margin (TTM)30.8%
Net margin (TTM)17.1%
SectorHealthcare
IndustryDrug Manufacturers - General
CountryCH
Data as of2025-12-28
Moat score
68/ 100

Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.

Full stock profile

Dive deeper into Roche Holding AG's moat claims, evidence, and risks.

View ROG analysis

Thermo Fisher Scientific Inc.

TMO · New York Stock Exchange

Market cap (USD)$192B
Gross margin (TTM)39.5%
Operating margin (TTM)18%
Net margin (TTM)15.1%
SectorHealthcare
IndustryMedical - Diagnostics & Research
CountryUS
Data as of2025-12-22
Moat score
64/ 100

Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.

Full stock profile

Dive deeper into Thermo Fisher Scientific Inc.'s moat claims, evidence, and risks.

View TMO analysis

Comparison highlights

  • Moat score gap: Roche Holding AG leads (68 / 100 vs 64 / 100 for Thermo Fisher Scientific Inc.).
  • Segment focus: Roche Holding AG has 2 segments (76.3% in Pharmaceuticals); Thermo Fisher Scientific Inc. has 4 segments (53.6% in Laboratory Products and Biopharma Services).
  • Moat breadth: Roche Holding AG has 5 moat types across 3 domains; Thermo Fisher Scientific Inc. has 8 across 3.

Primary market context

Roche Holding AG

Pharmaceuticals

Market

Innovative (branded) prescription pharmaceuticals

Geography

Global

Customer

Healthcare providers and systems (hospitals/clinics), payers/governments, and patients

Role

Innovator pharmaceutical developer, manufacturer and marketer

Revenue share

76.3%

Thermo Fisher Scientific Inc.

Laboratory Products and Biopharma Services

Market

Laboratory supplies distribution/market channel plus outsourced biopharma services (CDMO/CRO)

Geography

Global

Customer

Pharma & biotech; academic/government labs; industrial and clinical laboratories

Role

Distributor/market channel and outsourced services provider

Revenue share

53.6%

Side-by-side metrics

Roche Holding AG
Thermo Fisher Scientific Inc.
Ticker / Exchange
ROG - SIX Swiss Exchange
TMO - New York Stock Exchange
Market cap (USD)
$292.8B
$192B
Gross margin (TTM)
73.4%
39.5%
Operating margin (TTM)
30.8%
18%
Net margin (TTM)
17.1%
15.1%
Sector
Healthcare
Healthcare
Industry
Drug Manufacturers - General
Medical - Diagnostics & Research
HQ country
CH
US
Primary segment
Pharmaceuticals
Laboratory Products and Biopharma Services
Market structure
Competitive
Competitive
Market share
n/a
n/a
HHI estimate
n/a
n/a
Pricing power
Moderate
Moderate
Moat score
68 / 100
64 / 100
Moat domains
Legal, Supply, Demand
Demand, Supply, Legal
Last update
2025-12-28
2025-12-22

Moat coverage

Shared moat types

Installed Base ConsumablesRegulated Standards Pipe

Roche Holding AG strengths

IP Choke PointCapex Knowhow ScaleData Workflow Lockin

Thermo Fisher Scientific Inc. strengths

Format Lock InBrand TrustService Field NetworkDistribution ControlProcurement InertiaCapacity Moat

Segment mix

Roche Holding AG segments

Full profile >

Pharmaceuticals

Competitive

76.3%

Diagnostics

Oligopoly

23.7%

Thermo Fisher Scientific Inc. segments

Full profile >

Life Sciences Solutions

Oligopoly

19%

Analytical Instruments

Oligopoly

17%

Specialty Diagnostics

Oligopoly

10.4%

Laboratory Products and Biopharma Services

Competitive

53.6%

Want the full wide moat stocks list?

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Proven models entering the expansion stage with unit economics that work.

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Curation & Accuracy

This directory blends AI‑assisted discovery with human curation. Entries are reviewed, edited, and organized with the goal of expanding coverage and sharpening quality over time. Your feedback helps steer improvements (because no single human can capture everything all at once).

Details change. Pricing, features, and availability may be incomplete or out of date. Treat listings as a starting point and verify on the provider’s site before making decisions. If you spot an error or a gap, send a quick note and I’ll adjust.