VOL. XCIV, NO. 247
★ WIDE MOAT STOCKS COMPARISON ★
NO ADVICE
Sunday, January 11, 2026
Stock Comparison
Amazon.com, Inc. vs Vertex Pharmaceuticals Incorporated
Compare moat strength, market structure, and segment coverage to understand how each company defends its edge.
Amazon.com, Inc.
AMZN · NASDAQ
Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.
Full stock profile
Dive deeper into Amazon.com, Inc.'s moat claims, evidence, and risks.
View AMZN analysisVertex Pharmaceuticals Incorporated
VRTX · NASDAQ
Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.
Full stock profile
Dive deeper into Vertex Pharmaceuticals Incorporated's moat claims, evidence, and risks.
View VRTX analysisComparison highlights
- Moat score gap: Vertex Pharmaceuticals Incorporated leads (99 / 100 vs 87 / 100 for Amazon.com, Inc.).
- Segment focus: Amazon.com, Inc. has 4 segments (73.5% in Amazon Stores (Retail, Marketplace, Prime Subscriptions)); Vertex Pharmaceuticals Incorporated has 3 segments (99.9% in Cystic Fibrosis CFTR Modulators).
- Primary market structure: Oligopoly vs Quasi-Monopoly. Pricing power: Moderate vs Strong.
- Moat breadth: Amazon.com, Inc. has 10 moat types across 4 domains; Vertex Pharmaceuticals Incorporated has 7 across 4.
Primary market context
Amazon.com, Inc.
Amazon Stores (Retail, Marketplace, Prime Subscriptions)
US retail ecommerce marketplace and online retail (integrated fulfillment + membership shipping)
United States
Consumers and third-party merchants
Marketplace operator, retailer, and fulfillment provider
73.5%
Vertex Pharmaceuticals Incorporated
Cystic Fibrosis CFTR Modulators
CFTR modulator therapies for cystic fibrosis
U.S., Europe, Australia, Canada
Patients (via specialty pharmacies/payers); CF care centers
Drug developer/manufacturer
99.9%
Side-by-side metrics
Moat coverage
Shared moat types
No overlap yet.
Amazon.com, Inc. strengths
Vertex Pharmaceuticals Incorporated strengths
Segment mix
Amazon.com, Inc. segments
Full profile >Amazon Web Services (AWS)
Oligopoly
Amazon Stores (Retail, Marketplace, Prime Subscriptions)
Oligopoly
Advertising Services (Amazon Ads / Retail Media)
Oligopoly
Other (healthcare, content licensing/distribution, shipping services, co-branded credit card agreements, etc.)
Competitive
Vertex Pharmaceuticals Incorporated segments
Full profile >Cystic Fibrosis CFTR Modulators
Quasi-Monopoly
Hemoglobinopathies Gene Therapy (CASGEVY)
Oligopoly
Acute Pain (JOURNAVX)
Competitive
Want the full wide moat stocks list?
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Proven models entering the expansion stage with unit economics that work.
View expansion-stage stocksCuration & Accuracy
This directory blends AI‑assisted discovery with human curation. Entries are reviewed, edited, and organized with the goal of expanding coverage and sharpening quality over time. Your feedback helps steer improvements (because no single human can capture everything all at once).
Details change. Pricing, features, and availability may be incomplete or out of date. Treat listings as a starting point and verify on the provider’s site before making decisions. If you spot an error or a gap, send a quick note and I’ll adjust.