WIDE MOAT STOCKS COMPARISON

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Stock Comparison

AstraZeneca PLC vs Pfizer Inc.

Compare moat strength, market structure, and segment coverage to understand how each company defends its edge.

AstraZeneca PLC

AZN · London Stock Exchange

Market cap (USD)$251.7B
Gross margin (TTM)79.3%
Operating margin (TTM)22.7%
Net margin (TTM)17%
SectorHealthcare
IndustryPharmaceuticals
CountryGB
Data as of2026-08-23
69/100
Moat score

Weighted across the company's segments.

Full stock profile

Dive deeper into AstraZeneca PLC's moat claims, evidence, and risks.

View AZN analysis

Pfizer Inc.

PFE · New York Stock Exchange

Market cap (USD)$159.5B
Gross margin (TTM)73.2%
Operating margin (TTM)21.7%
Net margin (TTM)6.8%
SectorHealthcare
IndustryPharmaceuticals
CountryUS
Data as of2026-08-23
58/100
Moat score

Weighted across the company's segments.

Full stock profile

Dive deeper into Pfizer Inc.'s moat claims, evidence, and risks.

View PFE analysis

Comparison highlights

  • Moat score gap: AstraZeneca PLC leads (69 / 100 vs 58 / 100 for Pfizer Inc.).
  • Segment focus: AstraZeneca PLC has 6 segments (46% in Oncology); Pfizer Inc. has 5 segments (37.5% in Primary Care).
  • Primary market structure: Oligopoly vs Oligopoly. Pricing power: Strong vs Moderate.
  • Moat breadth: AstraZeneca PLC has 1 moat types across 1 domains; Pfizer Inc. has 1 across 1.

Primary market context

AstraZeneca PLC

Oncology

Market

Innovator oncology therapeutics (branded prescription medicines)

Geography

Global

Customer

Hospitals, oncology clinics, payers

Role

Innovator biopharmaceutical company

Revenue share

46%

Pfizer Inc.

Primary Care

Market

Branded primary care medicines and vaccines (incl. cardiovascular, migraine, pneumococcal/RSV/COVID-19)

Geography

Global

Customer

Healthcare providers, payers/PBMs, pharmacies/wholesalers, and government procurement

Role

Innovator biopharma (R&D + manufacturing + commercialization)

Revenue share

37.5%

Side-by-side metrics

AstraZeneca PLC
Pfizer Inc.
Ticker / Exchange
AZN - London Stock Exchange
PFE - New York Stock Exchange
Market cap (USD)
$251.7B
$159.5B
Gross margin (TTM)
79.3%
73.2%
Operating margin (TTM)
22.7%
21.7%
Net margin (TTM)
17%
6.8%
Sector
Healthcare
Healthcare
Industry
Pharmaceuticals
Pharmaceuticals
HQ country
GB
US
Primary segment
Oncology
Primary Care
Market structure
Oligopoly
Oligopoly
Market share
n/a
n/a
HHI estimate
n/a
n/a
Pricing power
Strong
Moderate
Moat score
69 / 100
58 / 100
Moat domains
Legal
Legal
Last update
2026-09-05
2026-09-05

Moat coverage

Shared moat types

IP Choke Point

AstraZeneca PLC strengths

No unique moat types yet.

Pfizer Inc. strengths

No unique moat types yet.

Segment mix

AstraZeneca PLC segments

Full profile >

Oncology

Oligopoly

46%

Cardiovascular, Renal and Metabolism (CVRM)

Competitive

19.9%

Respiratory & Immunology (R&I)

Oligopoly

15.5%

Infectious Disease

Oligopoly

1%

Rare Disease

Oligopoly

16%

Other Medicines

Competitive

1.6%

Pfizer Inc. segments

Full profile >

Primary Care

Oligopoly

37.5%

Specialty Care

Oligopoly

21.3%

Oncology

Competitive

27.1%

Hospital and Biosimilars

Competitive

11.9%

Pfizer CentreOne

Competitive

2.2%

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Curation & Accuracy

This directory blends AI‑assisted discovery with human curation. Entries are reviewed, edited, and organized with the goal of expanding coverage and sharpening quality over time. Your feedback helps steer improvements (because no single human can capture everything all at once).

Details change. Pricing, features, and availability may be incomplete or out of date. Treat listings as a starting point and verify on the provider’s site before making decisions. If you spot an error or a gap, send a quick note and I’ll adjust.