VOL. XCIV, NO. 247
★ WIDE MOAT STOCKS COMPARISON ★
NO ADVICE
Saturday, January 10, 2026
Stock Comparison
Microsoft Corporation vs Vertex Pharmaceuticals Incorporated
Compare moat strength, market structure, and segment coverage to understand how each company defends its edge.
Microsoft Corporation
MSFT · Nasdaq Global Select Market
Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.
Full stock profile
Dive deeper into Microsoft Corporation's moat claims, evidence, and risks.
View MSFT analysisVertex Pharmaceuticals Incorporated
VRTX · NASDAQ
Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.
Full stock profile
Dive deeper into Vertex Pharmaceuticals Incorporated's moat claims, evidence, and risks.
View VRTX analysisComparison highlights
- Moat score gap: Vertex Pharmaceuticals Incorporated leads (99 / 100 vs 84 / 100 for Microsoft Corporation).
- Segment focus: Microsoft Corporation has 3 segments (42.9% in Productivity and Business Processes); Vertex Pharmaceuticals Incorporated has 3 segments (99.9% in Cystic Fibrosis CFTR Modulators).
- Primary market structure: Oligopoly vs Quasi-Monopoly. Pricing power: Strong vs Strong.
- Moat breadth: Microsoft Corporation has 9 moat types across 4 domains; Vertex Pharmaceuticals Incorporated has 7 across 4.
Primary market context
Microsoft Corporation
Productivity and Business Processes
Enterprise productivity & collaboration suites, business applications, and professional network platforms
Global
Enterprises, SMBs, consumers, recruiters/advertisers
SaaS platform + professional network
42.9%
Vertex Pharmaceuticals Incorporated
Cystic Fibrosis CFTR Modulators
CFTR modulator therapies for cystic fibrosis
U.S., Europe, Australia, Canada
Patients (via specialty pharmacies/payers); CF care centers
Drug developer/manufacturer
99.9%
Side-by-side metrics
Moat coverage
Shared moat types
No overlap yet.
Microsoft Corporation strengths
Vertex Pharmaceuticals Incorporated strengths
Segment mix
Microsoft Corporation segments
Full profile >Productivity and Business Processes
Oligopoly
Intelligent Cloud
Oligopoly
More Personal Computing
Quasi-Monopoly
Vertex Pharmaceuticals Incorporated segments
Full profile >Cystic Fibrosis CFTR Modulators
Quasi-Monopoly
Hemoglobinopathies Gene Therapy (CASGEVY)
Oligopoly
Acute Pain (JOURNAVX)
Competitive
Want the full wide moat stocks list?
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View the moat stocks listLooking for expansion-stage stocks?
Proven models entering the expansion stage with unit economics that work.
View expansion-stage stocksCuration & Accuracy
This directory blends AI‑assisted discovery with human curation. Entries are reviewed, edited, and organized with the goal of expanding coverage and sharpening quality over time. Your feedback helps steer improvements (because no single human can capture everything all at once).
Details change. Pricing, features, and availability may be incomplete or out of date. Treat listings as a starting point and verify on the provider’s site before making decisions. If you spot an error or a gap, send a quick note and I’ll adjust.