VOL. XCIV, NO. 247
★ WIDE MOAT STOCKS COMPARISON ★
NO ADVICE
Tuesday, December 30, 2025
Stock Comparison
Gilead Sciences, Inc. vs Roche Holding AG
Compare moat strength, market structure, and segment coverage to understand how each company defends its edge.
Gilead Sciences, Inc.
GILD · NASDAQ Global Select Market
Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.
Full stock profile
Dive deeper into Gilead Sciences, Inc.'s moat claims, evidence, and risks.
View GILD analysisRoche Holding AG
ROG · SIX Swiss Exchange
Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.
Full stock profile
Dive deeper into Roche Holding AG's moat claims, evidence, and risks.
View ROG analysisComparison highlights
- Moat score gap: Gilead Sciences, Inc. leads (74 / 100 vs 68 / 100 for Roche Holding AG).
- Segment focus: Gilead Sciences, Inc. has 5 segments (68.5% in HIV); Roche Holding AG has 2 segments (76.3% in Pharmaceuticals).
- Primary market structure: Oligopoly vs Competitive. Pricing power: Moderate vs Moderate.
- Moat breadth: Gilead Sciences, Inc. has 8 moat types across 3 domains; Roche Holding AG has 5 across 3.
Primary market context
Gilead Sciences, Inc.
HIV
HIV treatment and prevention medicines (antiretroviral therapy and PrEP)
Global (U.S. and Europe are major markets)
Patients/prescribers; reimbursed by public and private payers; distributed via wholesalers and specialty pharmacies
Drug developer and marketing authorization holder
68.5%
Roche Holding AG
Pharmaceuticals
Innovative (branded) prescription pharmaceuticals
Global
Healthcare providers and systems (hospitals/clinics), payers/governments, and patients
Innovator pharmaceutical developer, manufacturer and marketer
76.3%
Side-by-side metrics
Moat coverage
Shared moat types
Gilead Sciences, Inc. strengths
Roche Holding AG strengths
Segment mix
Gilead Sciences, Inc. segments
Full profile >HIV
Oligopoly
Oncology (Cell Therapy + Trodelvy)
Oligopoly
Liver Disease
Oligopoly
Veklury (Remdesivir)
Competitive
Other Products
Competitive
Roche Holding AG segments
Full profile >Pharmaceuticals
Competitive
Diagnostics
Oligopoly
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View the moat stocks listCuration & Accuracy
This directory blends AI‑assisted discovery with human curation. Entries are reviewed, edited, and organized with the goal of expanding coverage and sharpening quality over time. Your feedback helps steer improvements (because no single human can capture everything all at once).
Details change. Pricing, features, and availability may be incomplete or out of date. Treat listings as a starting point and verify on the provider’s site before making decisions. If you spot an error or a gap, send a quick note and I’ll adjust.