VOL. XCIV, NO. 247

★ WIDE MOAT STOCKS COMPARISON ★

NO ADVICE

Wednesday, December 31, 2025

Stock Comparison

Gilead Sciences, Inc. vs Stryker Corporation

Compare moat strength, market structure, and segment coverage to understand how each company defends its edge.

Gilead Sciences, Inc.

GILD · NASDAQ Global Select Market

Market cap (USD)$155.6B
SectorHealthcare
CountryUS
Data as of2025-12-30
Moat score
74/ 100

Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.

Full stock profile

Dive deeper into Gilead Sciences, Inc.'s moat claims, evidence, and risks.

View GILD analysis

Stryker Corporation

SYK · New York Stock Exchange

Market cap (USD)$141.3B
SectorHealthcare
CountryUS
Data as of2025-12-30
Moat score
71/ 100

Weighted average of segment moat scores, combining moat strength, durability, confidence, market structure, pricing power, and market share.

Full stock profile

Dive deeper into Stryker Corporation's moat claims, evidence, and risks.

View SYK analysis

Comparison highlights

  • Moat score gap: Gilead Sciences, Inc. leads (74 / 100 vs 71 / 100 for Stryker Corporation).
  • Segment focus: Gilead Sciences, Inc. has 5 segments (68.5% in HIV); Stryker Corporation has 2 segments (59.8% in MedSurg and Neurotechnology).
  • Moat breadth: Gilead Sciences, Inc. has 8 moat types across 3 domains; Stryker Corporation has 5 across 3.

Primary market context

Gilead Sciences, Inc.

HIV

Market

HIV treatment and prevention medicines (antiretroviral therapy and PrEP)

Geography

Global (U.S. and Europe are major markets)

Customer

Patients/prescribers; reimbursed by public and private payers; distributed via wholesalers and specialty pharmacies

Role

Drug developer and marketing authorization holder

Revenue share

68.5%

Stryker Corporation

MedSurg and Neurotechnology

Market

Hospital medical devices: surgical equipment and navigation, endoscopy and visualization, patient handling and emergency care, neurosurgical and neurovascular devices

Geography

Global

Customer

Hospitals and ambulatory surgery centers; clinicians

Role

Medical device OEM + distributor/service provider

Revenue share

59.8%

Side-by-side metrics

Gilead Sciences, Inc.
Stryker Corporation
Ticker / Exchange
GILD - NASDAQ Global Select Market
SYK - New York Stock Exchange
Market cap (USD)
$155.6B
$141.3B
Sector
Healthcare
Healthcare
HQ country
US
US
Primary segment
HIV
MedSurg and Neurotechnology
Market structure
Oligopoly
Oligopoly
Market share
50%-60% (reported)
n/a
HHI estimate
n/a
n/a
Pricing power
Moderate
Moderate
Moat score
74 / 100
71 / 100
Moat domains
Demand, Legal, Supply
Supply, Demand, Legal
Last update
2025-12-30
2025-12-30

Moat coverage

Shared moat types

IP Choke PointService Field NetworkCompliance AdvantageBrand Trust

Gilead Sciences, Inc. strengths

Habit DefaultSwitching Costs GeneralCapex Knowhow ScaleRegulated Standards Pipe

Stryker Corporation strengths

Training Org Change Costs

Segment mix

Gilead Sciences, Inc. segments

Full profile >

HIV

Oligopoly

68.5%

Oncology (Cell Therapy + Trodelvy)

Oligopoly

11.5%

Liver Disease

Oligopoly

10.6%

Veklury (Remdesivir)

Competitive

6.3%

Other Products

Competitive

3.1%

Stryker Corporation segments

Full profile >

MedSurg and Neurotechnology

Oligopoly

59.8%

Orthopaedics

Oligopoly

40.2%

Want the full wide moat stocks list?

Browse the full ranking of wide moat stocks, updated with moat scores and segment context.

View the moat stocks list

Curation & Accuracy

This directory blends AI‑assisted discovery with human curation. Entries are reviewed, edited, and organized with the goal of expanding coverage and sharpening quality over time. Your feedback helps steer improvements (because no single human can capture everything all at once).

Details change. Pricing, features, and availability may be incomplete or out of date. Treat listings as a starting point and verify on the provider’s site before making decisions. If you spot an error or a gap, send a quick note and I’ll adjust.